Santa Rosa is a community in the Barima- Waini region of northern Guyana.Its population is approximately 10,000. 

Santa Rosa is the largest Amerindian village in Guyana. This predominantly Arawak village is located on the Moruka River, 29 km from its mouth. The village is actually a collection of at least ten settlements spread out in the Savannah wetlands along a ten mile stretch of the Moruka River. Santa Rosa is one of the earliest Catholic Missions in Guyana. Its name is in Spanish (in English be Saint Rose).